Thursday, May 23, 2013
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levels to diagnose preeclampsia
Mouse studies suggest
monitoring levels of ADM or its receptor, CRLR, could enable early diagnosis
of preeclampsia in pregnant women. In mice, placentas of Adm- or Crlr-deficient
mouse fetuses showed less remodeling of vasculature and greater recruitment
of maternal uterine NK cells, which are features of preeclampsia, than
placentas of wild-type mouse fetuses. In maternal uterine NK cells from
normal mice, Adm increased the secretion of cytokines, chemokines and
metalloproteases involved in remodeling of placental vasculature compared
with no treatment. Planned studies include investigating serum ADM as a
marker of preeclampsia in pregnant women (see Revisiting
adrenomedullin in pre-eclampsia, page 5).
Published online May 23, 2013
Unpatented; unlicensed; Adm-deficient
mouse models available for partnering
Li, M. et al. J. Clin.
Invest.; published online May 1, 2013;
Contact: Kathleen M. Caron, The University of North Carolina at Chapel
Hill School of Medicine, Chapel Hill, N.C.
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