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Adrenomedullin (ADM; AM) and calcitonin receptor-like (CRLR; CALCRL) levels to diagnose preeclampsia

Mouse studies suggest monitoring levels of ADM or its receptor, CRLR, could enable early diagnosis of preeclampsia in pregnant women. In mice, placentas of Adm- or Crlr-deficient mouse fetuses showed less remodeling of vasculature and greater recruitment of maternal uterine NK cells, which are features of preeclampsia, than placentas of wild-type mouse fetuses. In maternal uterine NK cells from normal mice, Adm increased the secretion of cytokines, chemokines and metalloproteases involved in remodeling of placental vasculature compared with no treatment. Planned studies include investigating serum ADM as a marker of preeclampsia in pregnant women (see Revisiting adrenomedullin in pre-eclampsia, page 5).

SciBX 6(20); doi:10.1038/scibx.2013.505
Published online May 23, 2013

Unpatented; unlicensed; Adm-deficient mouse models available for partnering

Li, M. et al. J. Clin. Invest.; published online May 1, 2013;
Contact: Kathleen M. Caron, The University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, N.C.