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Drug delivery

Collagen-like, cell-penetrating peptides for drug delivery

Cell-penetrating peptides structurally similar to collagen could be used to deliver therapeutics into cells. The peptides contain a collagen-like, triple-helical scaffold that can resist cleavage by proteases. In cell culture, peptides conjugated with a toxin complex that induces cell death after entering the cytosol decreased cell viability compared with unconjugated peptides. In human serum, the collagen-like peptides had a longer half-life than related peptides that lacked the triple-helical scaffold. Next steps could include evaluating the use of the collagen-like peptides for drug delivery.

SciBX 6(20); doi:10.1038/scibx.2013.500
Published online May 23, 2013

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Yamazaki, C.M. et al. Angew. Chem. Int. Ed.; published online April 16, 2013;
Contact: Takaki Koide, Waseda University, Tokyo, Japan