Thursday, May 23, 2013
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model for metastatic breast cancer
A mouse model for
postsurgical resection metastatic breast cancer could be useful for
evaluating therapeutic regimens to treat the disease. In mice with metastatic
human breast cancer, Sutent
when given after surgical resection of the primary tumor did not
significantly increase survival compared with vehicle. However, an antibody
against rodent Vegf
receptor 2 (Kdr/Flk-1;
when given after resection of the primary tumor increased survival compared
with either compound alone or vehicle. Next steps could include using the
model to predict efficacy of therapeutic regimens.
Pfizer Inc. markets the receptor
tyrosine kinase (RTK)
inhibitor Sutent sunitinib to treat gastrointestinal stromal tumors (GISTs)
and advanced renal cell carcinoma (RCC). The drug was discontinued in
advanced breast cancer after missing the endpoints in Phase III trials.
Paclitaxel is a generic platinum chemotherapy drug.
Published online May 23, 2013
Patent and licensing status
Guerin, E. et al. Cancer
Res.; published online April 22, 2013;
Contact: Robert S. Kerbel, University of Toronto, Toronto, Ontario, Canada
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