Thursday, May 9, 2013
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Medial ganglionic eminence
(MGE)-like progenitor cell transplantation to treat memory and learning
Cell culture and mouse
studies suggest transplantation of MGE-like progenitor cells could help treat
learning and memory deficits. Human embryonic stem cells were induced into
MGE-like progenitor cells that could differentiate into basal forebrain
cholinergic neurons and g-aminobutyric
interneurons. In mice with immunotoxin-mediated destruction of hippocampal
basal forebrain cholinergic neurons and GABA neurons, hippocampal
transplantation of the human MGE progenitor cells increased memory, learning
and spatial cognition compared with transplantation of human spinal
progenitor cells. Next steps could include testing the procedure in animal
models for neurodegeneration or neurological disease.
Published online May 9, 2013
Patent and licensing status
Liu, Y. et al. Nat.
Biotechnol.; published online April 21, 2013;
Contact: Su-Chun Zhang, University of Wisconsin-Madison,
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