Thursday, May 2, 2013
This week in techniques
Publication and contact
Assays & screens
microfluidic platform for the isolation of epithelial
cell adhesion molecule (EpCAM)-positive
and EpCAM-negative circulating tumor cells (CTCs) from blood samples
throughput, microfluidic platform called the CTC-iChip could help guide
cancer diagnosis and prognosis. The platform separates CTCs from the blood
via a series of steps involving microfluidic methods for rare cell handling
and magnetic-based cell sorting. The CTC-iChip was used to isolate EpCAM-positive
CTCs from the blood of patients with prostate, lung, breast, pancreatic or
colorectal cancer and EpCAM-negative CTCs from the blood of patients with
metastatic breast cancer, pancreatic cancer or melanoma. The CTCs were of
sufficient quality that they could be characterized using
immunohistochemistry, RNA molecular analysis or gene expression profiling.
Next steps include adding molecular assay components to the device (see
CTCs gain character(ization), page 8).
Published online May 2, 2013
Multiple patents covering
various aspects of the technology at different stages of filing; exclusively
licensed to Johnson
Ozkumur, E. et al. Sci.
Transl. Med.; published online April 3, 2013;
Contact: Mehmet Toner, Harvard Medical School, Boston, Mass.
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