Thursday, April 18, 2013
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Rational design of HIV gp120 immunogen to
induce broadly neutralizing antibodies
HIV gp120 immunogen
complexes could be used to induce the production of broadly neutralizing HIV
antibodies. The native HIV gp120 antigen does not engage germline precursor B cell
receptors that give rise to broadly neutralizing anti-HIV
antibodies. An immunogen was created from gp120 by removing specific
glycosylated residues, and multimers of the resulting protein were conjugated
to nanoparticles. The immunogen complex bound and activated germline
precursor B cell receptors, whereas a monomeric control antigen did not. Next
steps include evaluating the complex in humanized mice expressing B cell
receptors that recognize the immunogen.
SciBX 6(15); doi:10.1038/scibx.2013.377
Published online April 18, 2013
Patent application filed
for findings in both studies; available for licensing
Jardine, J. et al.
Science; published online March 28, 2013;
Contact: William R. Schief, The Scripps Research Institute,
La Jolla, Calif.
McGuire, A.T. et al. J. Exp. Med.; published online March 25, 2013;
Contact: Leonidas Stamatatos, Seattle Biomedical Research
Institute, Seattle, Wash.
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