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Drug delivery

A peptide fragment based on CD47 to prolong circulation time and improve nanoparticle delivery

Mouse studies identified a CD47-derived peptide that could improve the bioavailability of nanoparticle drug delivery vehicles. In mice, nanobeads linked to human CD47 or a synthetic peptide that mimics the binding region of CD47 showed better circulation than a scrambled peptide or nanobeads alone. In mice with human lung cancer xenografts, nanobeads that were loaded with paclitaxel and expressed the minimal CD47 peptide showed greater accumulation in the tumor tissues than paclitaxel alone. Next steps include testing the peptide as an aid to delivering other therapeutics.

SciBX 6(10); doi:10.1038/scibx.2013.247
Published online March 14, 2013

Patent application filed; unavailable for licensing

Rodriguez, P.L. et al. Science; published online Feb. 22, 2013;
Contact: Dennis E. Discher, University of Pennsylvania, Philadelphia, Pa.