Thursday, February 21, 2013
This week in techniques
Publication and contact
Mouse model for proteolytic
clearance of plasma b-amyloid (Ab)
Mouse studies suggest
reducing plasma Ab levels may not be sufficient to decrease Ab
in the CNS. Reducing plasma Ab levels has been
suggested as a strategy to decrease CNS Ab by acting as
an efflux sink for the peptide. In both wild-type mice and a mouse model for
Ab-driven Alzheimer's disease (AD), peripheral
infusion of recombinant neutral endopeptidase (neprilysin;
an Ab-cleaving metalloprotease, decreased plasma Ab
levels compared with saline infusion but did not decrease Ab
levels in the brain and cerebrospinal fluid. Researchers did not disclose
next steps, which could include replicating the studies with other classes of
compounds that deplete peripheral Ab levels.
Published online Feb. 21, 2013
Patent and licensing status
Walker, J.R. et al. J.
published online Feb. 6, 2013;
Contact: Andrew M. Schumacher, Genomics Institute of the
Novartis Research Foundation, San Diego, Calif.
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