Thursday, February 14, 2013
Publication and contact
Highly prevalent telomerase reverse transcriptase
mutations in melanoma
Two independent studies
identified highly prevalent mutations upstream of TERT that could help
guide the development of new treatments for melanoma. In a family with
members diagnosed with melanoma, sequencing studies identified mutations
upstream of TERT in all affected individuals. In sporadic melanoma
cases, one study identified mutations upstream of TERT in 33% of
primary tumors and 85% of metastatic tumors, whereas the second study
identified mutations upstream of TERT in 71% of melanoma samples. In
cells carrying the mutations, TERT expression was greater than that in cells
without such mutations. Next steps include additional studies evaluating the
functional consequences of these mutations and the effect of TERT inhibition
in this population.
Published online Feb. 14, 2013
Findings in both studies
unpatented; licensing status not applicable
Huang, F.W. et al.
Science; published online Jan. 24, 2013;
Contact: Levi A. Garraway, Broad Institute of MIT and
Harvard, Cambridge, Mass.
Horn, S. et al. Science; published online Jan. 24, 2013;
Contact: Rajiv Kumar, German Cancer Research Center,
Contact: Susanne Horn, same affiliation as above
Contact: Dirk Schadendorf, Essen
University Hospital, Essen, Germany
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]