Thursday, January 17, 2013
Publication and contact
Targeting ventral tegmental
area (VTA) dopaminergic neurons to treat depression
Targeting a subset of
dopaminergic neurons could be useful for reducing depression-related
behaviors. In mice, optogenetic induction of a phasic firing pattern in VTA
dopaminergic neurons in mice increased susceptibility to social defeat stress
and depression-related behaviors compared with induction of a tonic firing
pattern. In mice and rats, optogenetic inhibition of VTA dopaminergic neurons
increased depression-related behaviors compared with no inhibition. Next
steps could include developing pharmacological agents to modulate the
activity of VTA neurons.
Published online Jan. 17, 2013
Patent and licensing status
for both studies unavailable
Chaudhury, D. et al.
Nature; published online Dec. 12, 2012;
Contact: Ming-Hu Han, Mount Sinai School of Medicine,
New York, N.Y.
Tye, K.M. et al. Nature; published online Dec. 12, 2012;
Contact: Karl Deisseroth, Stanford University, Stanford,
All contents Copyright © 1993-2015 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]