Thursday, January 17, 2013
Publication and contact
Direct conversion of
quiescent cardiomyocytes into pacemaker cells
gene therapy approach for direct conversion of quiescent cardiomyocytes into
pacemaker cells could be useful for treating arrhythmias. In cultured rat
ventricular myocytes, adenoviral vector expression of T-box
18 (Tbx18) resulted in the formation
of monolayers of spontaneously beating cells. In guinea pigs, cardiac
injection of the adenovirus vector encoding Tbx18 led to pacemaker
activity at the site of injection, whereas injection of the same vector
encoding a control protein did not. Next steps include validating the results
in a large animal model and evaluating the safety and pharmacokinetics of the
Published online Jan. 17, 2013
Patent and licensing status
Kapoor, N. et al. Nat.
Biotechnol.; published online Dec. 16, 2012;
Contact: Eduardo Marbán,
Cedars-Sinai Medical Center,
Los Angeles, Calif.
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