Thursday, January 17, 2013
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pH (low) insertion peptides
(pHLIPs) for drug delivery to ischemic myocardium
pHLIPs could be useful for
delivering imaging agents or therapeutics to ischemic regions of the heart
that have lower pH values than nonischemic regions. pHLIPs are water-soluble
polypeptides derived from the bacteriorhodopsin C helix. In mice with
ischemia in different regions of the heart, injection of dye-conjugated
pHLIPs increased fluorescence signal in ischemic regions compared with
nonischemic regions. In isolated mouse hearts subjected to ischemia,
dye-loaded pHLIP-coated liposomes increased fluorescence signal compared with
that in nonischemic hearts. Next steps include evaluating the pHLIP
technology to deliver imaging and therapeutic agents in additional models of
Published online Jan. 17, 2013
Covered by multiple issued
and pending patents; use of radionuclide-labeled pHLIPs as a diagnostic tool
for imaging of acidic tissues licensed to General
Electric Co.; other diagnostic applications and all therapeutic
applications available for licensing
Sosunov, E.A. et al.
Proc. Natl. Acad. Sci. USA; published online
Dec. 17, 2012;
Contact: Oleg A. Andreev, University of Rhode Island, Kingston,
Contact: Donald M. Engelman, Yale University, New Haven, Conn.
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