Thursday, January 17, 2013
Publication and contact
pH (low) insertion peptides
(pHLIPs) for drug delivery to ischemic myocardium
pHLIPs could be useful for
delivering imaging agents or therapeutics to ischemic regions of the heart
that have lower pH values than nonischemic regions. pHLIPs are water-soluble
polypeptides derived from the bacteriorhodopsin C helix. In mice with
ischemia in different regions of the heart, injection of dye-conjugated
pHLIPs increased fluorescence signal in ischemic regions compared with
nonischemic regions. In isolated mouse hearts subjected to ischemia,
dye-loaded pHLIP-coated liposomes increased fluorescence signal compared with
that in nonischemic hearts. Next steps include evaluating the pHLIP
technology to deliver imaging and therapeutic agents in additional models of
Published online Jan. 17, 2013
Covered by multiple issued
and pending patents; use of radionuclide-labeled pHLIPs as a diagnostic tool
for imaging of acidic tissues licensed to General
Electric Co.; other diagnostic applications and all therapeutic
applications available for licensing
Sosunov, E.A. et al.
Proc. Natl. Acad. Sci. USA; published online
Dec. 17, 2012;
Contact: Oleg A. Andreev, University of Rhode Island, Kingston,
Contact: Donald M. Engelman, Yale University, New Haven, Conn.
All contents Copyright © 1993-2017 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]