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Drug delivery

pH (low) insertion peptides (pHLIPs) for drug delivery to ischemic myocardium  

pHLIPs could be useful for delivering imaging agents or therapeutics to ischemic regions of the heart that have lower pH values than nonischemic regions. pHLIPs are water-soluble polypeptides derived from the bacteriorhodopsin C helix. In mice with ischemia in different regions of the heart, injection of dye-conjugated pHLIPs increased fluorescence signal in ischemic regions compared with nonischemic regions. In isolated mouse hearts subjected to ischemia, dye-loaded pHLIP-coated liposomes increased fluorescence signal compared with that in nonischemic hearts. Next steps include evaluating the pHLIP technology to deliver imaging and therapeutic agents in additional models of ischemia.

SciBX 6(2); doi:10.1038/scibx.2013.44
Published online Jan. 17, 2013

Covered by multiple issued and pending patents; use of radionuclide-labeled pHLIPs as a diagnostic tool for imaging of acidic tissues licensed to General Electric Co.; other diagnostic applications and all therapeutic applications available for licensing

Sosunov, E.A. et al. Proc. Natl. Acad. Sci. USA; published online
Dec. 17, 2012;
Contact: Oleg A. Andreev, University of Rhode Island, Kingston, R.I.
Contact: Donald M. Engelman, Yale University, New Haven, Conn.