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Disease models

Mouse model for invasive lobular breast cancer metastasis

A mouse model for invasive lobular breast cancer metastasis could aid the understanding of metastasis and help test new therapeutic candidates. Wild-type mice were orthotopically implanted with invasive lobular carcinoma tumor fragments and then had a mastectomy after primary tumors were established. The majority of these mice died because of metastatic disease in the lymph nodes, lungs, liver and spleen. In the model, chemotherapy delayed the development of metastatic disease compared with saline. Next steps could include using the model to evaluate therapeutics that could prevent metastasis.

SciBX 5(48); doi:10.1038/scibx.2012.1269
Published online Dec. 13, 2012

Unpatented; available for licensing

Doornebal, C.W. et al. Cancer Res.; published online Nov. 14, 2012;
Contact: Karin E. de Visser, The Netherlands Cancer Institute, Amsterdam, the Netherlands