Thursday, December 13, 2012
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Assays & screens
Antibiotic mode of action
profile (BioMAP) screening to identify and classify antibiotics in natural
Comparing the inhibitory
profiles of natural product extracts with those of known classes of
antibiotics could help identify new antibiotic leads. MICs of 72 commercially
available antibiotics with multiple mechanisms of action were determined
against 15 bacterial strains. A computational analysis that compared the MIC
profiles of these known drugs with the MIC profile of natural product extract
fractions helped identify a structurally unique naphthoquinone
antibiotic with a distinct inhibitory profile. In vitro, the
antibiotic inhibited bacterial cell growth at 12.5-50 mM
concentrations. Next steps include screening a 5,000-member marine natural
product library to identify additional antibiotic scaffolds for development.
Published online Dec. 13, 2012
status not applicable; compounds can be screened on a fee-for-service basis
through the University
of California, Santa Cruz Chemical Screening Center
Wong, R.W. et al. Chem.
Biol.; published online Nov. 21, 2012;
Contact: Roger G. Linington, University of California, Santa
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