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Drug platforms

Method for generating disulfide-linked cyclic peptides

A method for generating disulfide-linked cyclic peptides could be useful as a platform for identifying new therapeutic leads. The method involves designing peptides with cysteine residues at appropriate intervals that result in their spontaneous folding into bicyclic or tricyclic structures. Next steps include identifying specific multicyclic scaffolds with high stability and resistance to degradation that can then be used to screen for therapeutic leads.

SciBX 5(46); doi:10.1038/scibx.2012.1219
Published online Nov. 29, 2012

Unpatented; licensing status not applicable

Wu, C. et al. Nat. Chem.; published online Oct. 28, 2012;
Contact: Marc A. Gauthier, Swiss Federal Institute of Technology Zurich (ETHZ), Zurich, Switzerland
Contact: Jean-Christophe Leroux, same affiliation as above