Thursday, November 15, 2012
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Microfluidic device to
model IL-2-induced pulmonary
In vitro studies suggest a microfluidic device could be used
to model pulmonary edema and identify molecules to prevent the disease. The
device consists of human alveolar epithelial cells and pulmonary
microvascular cells separated by a porous membrane that is subjected to
mechanical strain to mimic breathing. In the chip, exposure to IL-2, a cancer
therapy that causes pulmonary edema as a side effect, increased vascular
permeability and fluid leak into the alveolar air space compared with no
treatment. These effects were inhibited by angiopoietin 1 (ANG1; ANGPT1) or a transient receptor potential vanilloid 4 (TRPV4; VRL2) inhibitor. Next steps
include additional studies to confirm that data from the chips can replace
animal model data.
Published online Nov. 15, 2012
Patents filed; available
Huh, D. et al. Sci.
Transl. Med.; published online Nov. 11, 2012;
Contact: Donald E. Ingber, Harvard University,
Contact: Geraldine A. Hamilton, same affiliation as above
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