Thursday, November 8, 2012
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Transgenic rats expressing
as a model for Huntington's disease (HD)
Transgenic rats that
express full-length HTT could help identify new HD therapies. Rats
were generated that expressed a human bacterial artificial chromosome
encoding full-length HTT, including 97 CAG/CAA repeats and all
regulatory elements. The animals developed an early onset, progressive
HD-like phenotype that recapitulated motor and behavioral impairments as well
as brain histopathology. Next steps include a detailed cognitive
characterization of the rat model and additional in vivo imaging
Published online Nov. 8, 2012
Model unpatented; available
Yu-Taeger, L. et al. J.
published online Oct. 31, 2012;
Contact: Huu Phuc Nguyen, University of Tuebingen, Tuebingen,
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