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Disease models

Transgenic rats expressing full-length huntingtin (HTT) as a model for Huntington's disease (HD)

Transgenic rats that express full-length HTT could help identify new HD therapies. Rats were generated that expressed a human bacterial artificial chromosome encoding full-length HTT, including 97 CAG/CAA repeats and all regulatory elements. The animals developed an early onset, progressive HD-like phenotype that recapitulated motor and behavioral impairments as well as brain histopathology. Next steps include a detailed cognitive characterization of the rat model and additional in vivo imaging studies.

SciBX 5(44); doi:10.1038/scibx.2012.1172
Published online Nov. 8, 2012

Model unpatented; available for licensing

Yu-Taeger, L. et al. J. Neurosci.;
published online Oct. 31, 2012;
Contact: Huu Phuc Nguyen, University of Tuebingen, Tuebingen, Germany