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Assays & screens

Fluorescent sensor for g-aminobutyric acid (GABA) and GABA receptor ligands

A fluorescent sensor could be useful for measuring concentrations of GABA and GABA receptor ligands on the cell surface. The sensor system uses a fluorescent fusion protein of a GABA-binding protein and a synthetic ligand that competes with GABA binding to its receptor. The sensor system measured micromolar to millimolar GABA concentrations on the surface of a cultured mammalian cell line. Next steps include determining whether the sensor system can measure GABA concentrations in neural synapses.

SciBX 5(44); doi:10.1038/scibx.2012.1169
Published online Nov. 8, 2012

Patent application filed covering technology used in the sensor system; licensed to New England Biolabs Inc.

Masharina, A. et al. J. Am. Chem. Soc.; published online Oct. 24, 2012;
Contact: Kai Johnsson, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland