Thursday, October 18, 2012
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upconversion fluorescent nanoparticles (UCNs) as a photodynamic therapy agent
Mouse studies suggest UCNs
could be photosensitizers that enable photodynamic therapy in deep tissue,
which could be used to help treat cancer. UCNs were synthesized by coating NaYF4-based
nanoparticles with mesoporous silica, resulting in particles that emitted
visible light in response to stimulation with deeper tissue-penetrating
near-infrared light. In a mouse model of melanoma, intratumoral injection of
UCNs conjugated to two photosensitizer dyes followed by near-infrared
irradiation decreased tumor growth compared with intratumoral injection of
vehicle with no irradiation. Next steps include additional preclinical
efficacy studies in small and large animal models of cancer and preclinical
Published online Oct. 18, 2012
Patented; unavailable for
Idris, N.M. et al. Nat.
Med.; published online Sept. 16, 2012;
Contact: Yong Zhang, National University of Singapore, Singapore
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