Thursday, October 11, 2012
Publication and contact
Cell or tissue
transplantation to restore organ functions
Mouse studies suggest
transplantation of cells into lymph nodes could rescue organ function. In a
mouse model of lethal metabolic liver failure, transplantation of allogeneic
hepatocytes to lymph nodes led to engraftment, which rescued the animals from
liver failure. In athymic nude mice, transplantation of minced thymus tissue
to lymph nodes led to engraftment, production of T cells that were present in
the peripheral blood and immune responses against tumor cell transplants. In
a mouse model of diabetes, transplantation of islets to lymph nodes led to
engraftment and production of C-peptide and glucagon, and it restored blood
glucose levels to those of normal mice. Next steps include testing the method
Published online Oct. 11, 2012
Patent application filed;
available for licensing
Komori, J. et al. Nat.
Biotechnol.; published online Sept. 23, 2012;
Contact: Eric Lagasse, University of Pittsburgh School of
Medicine, Pittsburgh, Pa.
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]