Thursday, October 11, 2012
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Cell or tissue
transplantation to restore organ functions
Mouse studies suggest
transplantation of cells into lymph nodes could rescue organ function. In a
mouse model of lethal metabolic liver failure, transplantation of allogeneic
hepatocytes to lymph nodes led to engraftment, which rescued the animals from
liver failure. In athymic nude mice, transplantation of minced thymus tissue
to lymph nodes led to engraftment, production of T cells that were present in
the peripheral blood and immune responses against tumor cell transplants. In
a mouse model of diabetes, transplantation of islets to lymph nodes led to
engraftment and production of C-peptide and glucagon, and it restored blood
glucose levels to those of normal mice. Next steps include testing the method
Published online Oct. 11, 2012
Patent application filed;
available for licensing
Komori, J. et al. Nat.
Biotechnol.; published online Sept. 23, 2012;
Contact: Eric Lagasse, University of Pittsburgh School of
Medicine, Pittsburgh, Pa.
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