Thursday, October 4, 2012
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89Zr-transferrin agent for in vivo PET imaging
of transferrin receptor protein 1
(TFRC; TFR; CD71)-expressing cancers
PET imaging agent could help detect prostate and other cancers. The
TFRC-binding agent consisted of 89Zr-labeled desferrioxamine
conjugated to human transferrin. In mice with TFRC-expressing xenografts or
spontaneous prostate tumors, PET imaging of tumors with the 89Zr-transferrin
agent provided higher signal-to-noise ratios than 18F-labeled fluorodeoxyglucose
(FDG)-PET. In the spontaneous tumor
model, PET imaging with 89Zr-transferrin detected high-grade
prostate intraepithelial neoplasia (PIN), whereas 18F-FDG PET did
not. Ongoing work includes IND-enabling studies of the agent to image
undisclosed cancers (see Transferrin PET project, page 6).
Published online Oct. 4, 2012
J.P. et al. Nat Med.; published online Sept. 23, 2012;
Contact: Jason S. Lewis, Memorial Sloan-Kettering Cancer
Center, New York, N.Y.
Contact: Charles L. Sawyers, same affiliation as above
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