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Markers of squamous cell lung cancer

Genomic studies have identified recurrent mutations in squamous cell lung cancer samples that could be useful markers or therapeutic targets. Genetic analysis of 178 lung squamous cell carcinoma samples identified recurrent mutations in 11 genes, including previously unreported loss-of-function mutations in major histocompatibility complex class I A (HLA-A). The analysis showed that 96% of the tumors had mutations in potentially druggable targets such as tyrosine kinases, serine/threonine kinases and phosphoinositide 3-kinase (PI3K) subunits. Next steps could include using the data to define specific markers or gene signatures that could help identify squamous cell lung cancers that respond to existing targeted therapies.

SciBX 5(38); doi:10.1038/scibx.2012.1018
Published online Sept. 27, 2012

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The Cancer Genome Atlas Research Network. Nature; published online
Sept. 9, 2012;
Contact: Matthew Meyerson,
Broad Institute of MIT and Harvard, Cambridge, Mass.