Thursday, September 27, 2012
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Markers of squamous cell
Genomic studies have
identified recurrent mutations in squamous cell lung cancer samples that
could be useful markers or therapeutic targets. Genetic analysis of 178 lung
squamous cell carcinoma samples identified recurrent mutations in 11 genes,
including previously unreported loss-of-function mutations in major
histocompatibility complex class I A (HLA-A).
The analysis showed that 96% of the tumors had mutations in potentially
druggable targets such as tyrosine kinases, serine/threonine kinases and phosphoinositide
subunits. Next steps could include using the data to define specific markers
or gene signatures that could help identify squamous cell lung cancers that
respond to existing targeted therapies.
Published online Sept. 27, 2012
Patent and licensing status
The Cancer Genome Atlas
Research Network. Nature; published online
Sept. 9, 2012;
Contact: Matthew Meyerson,
Broad Institute of MIT and Harvard, Cambridge, Mass.
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