Licensing status

Publication and contact information

Drug delivery

Mixed mitochondria-targeted polymeric nanoparticles for drug delivery

Nanoparticles consisting of a mix of polymeric molecules could help improve drug delivery to the mitochondria. A mitochondria-targeting poly(lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) copolymer was blended with nontargeted polymers to generate nanoparticles with optimized size and surface charge. In a human cervical cancer cell line, nanoparticles containing the mitochondria-targeting copolymer showed greater uptake in mitochondria than nanoparticles that lacked the copolymer. In human and murine cell lines, the targeted nanoparticles increased the potency of mitochondria-acting compounds compared with nontargeted nanoparticles. In vivo studies to evaluate the polymeric nanoparticles are underway (see Slipping therapeutics to the mitochondria, page 8).

SciBX 5(38); doi:10.1038/scibx.2012.1017
Published online Sept. 27, 2012

Patent pending; available for licensing

Marrache, S. & Dhar, S. Proc. Natl. Acad. Sci. USA; published online Sept. 18, 2012;
Contact: Shanta Dhar, The University of Georgia, Athens, Ga.