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Disease models

Cystic fibrosis transmembrane conductance regulator (CFTR) knockout ferrets as models for cystic fibrosis-related diabetes

Cftr knockout ferrets could be useful models for cystic fibrosis-related diabetes. Cftr knockout ferrets had mild pancreatic pathology at birth and developed progressive pancreatic inflammation and exocrine pancreas destruction by the first month. The Cftr knockout animals also showed impaired glucose homeostasis and insulin regulation. Next steps include identifying islet cells that express CFTR and characterizing how CFTR modulates insulin secretion.

SciBX 5(38); doi:10.1038/scibx.2012.1012
Published online Sept. 27, 2012

Model unpatented; available for licensing

Olivier, A.K. et al. J. Clin. Invest.;
published online Sept. 17, 2012;
Contact: John F. Engelhardt, The University of Iowa, Iowa City, Iowa