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Disease models

Cell line-based culture system for generating human bocavirus

A cell line that generates human bocavirus 1 could be useful for developing vaccines and models of bocavirus infection. The genome of human bocavirus 1 was sequenced, cloned into a plasmid and inserted into the human embryonic kidney 293 (HEK293) cell line. In culture, the modified HEK293 cells generated human bocavirus 1 particles that infected primary human airway epithelial cells. Next steps could include conducting mutagenesis studies to identify attenuated strains for a vaccine, as well as screening for epitopes on the viral capsid that mediate infection of airway epithelia cells.

SciBX 5(37); doi:10.1038/scibx.2012.991
Published online Sept. 20, 2012

Provisional patent application filed; available for licensing from The University of Kansas Center for Technology Commercialization
Contact: Matthew Koenig, The University of Kansas Center for Technology Commercialization, Lawrence, Kan.
phone: 785-864-1774

Huang, Q. et al. PLoS Pathog.; published online Aug. 30, 2012;
Contact: Jianming Qiu,
The University of Kansas Medical Center, Kansas City, Kan.