Thursday, September 20, 2012
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Cell line-based culture
system for generating human bocavirus
A cell line that generates
human bocavirus 1 could be useful for developing vaccines and models of
bocavirus infection. The genome of human bocavirus 1 was sequenced, cloned
into a plasmid and inserted into the human embryonic kidney 293 (HEK293) cell
line. In culture, the modified HEK293 cells generated human bocavirus 1
particles that infected primary human airway epithelial cells. Next steps
could include conducting mutagenesis studies to identify attenuated strains
for a vaccine, as well as screening for epitopes on the viral capsid that
mediate infection of airway epithelia cells.
Published online Sept. 20, 2012
application filed; available for licensing from The University
of Kansas Center for Technology Commercialization
Contact: Matthew Koenig, The University of Kansas Center for
Technology Commercialization, Lawrence, Kan.
Huang, Q. et al. PLoS
Pathog.; published online Aug. 30, 2012;
Contact: Jianming Qiu,
The University of Kansas Medical Center, Kansas City, Kan.
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