Thursday, September 6, 2012
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Influenza vaccine to induce
broadly neutralizing antibodies
Mouse and ferret studies
suggest vaccines that induce broadly neutralizing antibodies may be useful
for preventing influenza virus infection, even in humans with previous
influenza exposure. Past human studies have suggested induction of broadly
neutralizing antibodies could be difficult in subjects with prior exposure to
influenza. In mice and ferrets with pre-existing immunity to an H1N1 influenza
A virus hemagglutinin (HA),
a prime and boost vaccination protocol against a second H1N1 HA induced
broadly neutralizing antibodies that protected the animals from challenge
with two other unmatched H1N1 strains. Next steps include using the
prime-boost vaccine strategy with an adjuvant in animal models of influenza
SciBX 5(35); doi:10.1038/scibx.2012.942
Published online Sept. 6, 2012
Patent application filed;
certain aspects available for licensing
Wei, C.-J. et al. Sci.
Transl. Med.; published online Aug. 15, 2012;
Contact: Gary J. Nabel, National Institutes of Health,
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