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Polyethyleneimine (PEI) as an adjuvant for intranasal vaccines

PEI could boost the efficacy of intranasal vaccines against viral infections. In mice intranasally immunized with an HIV gp140-based vaccine, coimmunization with PEI induced higher gp140-specific systemic and mucosal IgG levels than mucosal adjuvants a-galactosylceramide, cholera toxin B or cholera holotoxin. Mice immunized intranasally with PEI and vaccines against influenza A virus or herpes simplex virus (HSV)-2 had greater protection against challenge with live influenza A virus or HSV-2 than mice immunized with vaccine and a-galactosylceramide or cholera toxin-based adjuvants. Planned work includes testing PEI as an adjuvant to undisclosed bacterial vaccines in animal models.

SciBX 5(35); doi:10.1038/scibx.2012.941
Published online Sept. 6, 2012

Unpatented; available for partnering

Wegmann, F. et al. Nat. Biotechnol.; published online Aug. 26, 2012;
Contact: Quentin J. Sattentau, University of Oxford, Oxford, U.K.