Thursday, August 30, 2012
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Transgenic mouse model for
Transgenic mice with
astrocyte-specific overexpression of human heme oxygenase decycling 1
(HMOX1; HO-1; Hsp32) could be a useful
model for schizophrenia and other neurodevelopmental and neurodegenerative
diseases. In behavioral assays, the mice showed multiple schizophrenia-like
behaviors including hyperlocomotion and impaired prepulse inhibition. Brain
tissue samples showed multiple neuropathologies including altered hippocampal
cytoarchitecture, subcortical oxidative stress and mitochondrial damage. Next
steps include further characterizing the phenotype of the mice and using the
model to evaluate the effects of a brain-permeable HO-1 inhibitor from Osta Biotechnologies Inc.
OB-28 HO-1 inhibitor is in
preclinical development for Alzheimer's disease (AD).
Published online Aug. 30, 2012
Patent application filed;
available for licensing
Song, W. et al. J.
Neurosci.; published online Aug. 8, 2012;
Contact: Hyman M. Schipper, Jewish General Hospital, Montreal, Quebec, Canada
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