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VEGF-containing, self-assembling peptide nanofiber scaffolds for promoting arteriogenesis

VEGF-containing, self-assembling peptide nanofiber scaffolds could help promote tissue repair following myocardial infarction (MI). In rat and porcine models of MI, intramyocardial injection of the VEGF-containing nanofiber scaffold increased cardiac function, angiogenesis and arteriogenesis compared with injection of scaffold or VEGF alone. In the rat model, intramyocardial injection of the VEGF-containing nanofiber scaffold decreased systemic adverse effects compared with injection of VEGF itself. Next steps include studies to evaluate the scaffold's long-term effects and determine its therapeutic window in the post-MI setting.

SciBX 5(33); doi:10.1038/scibx.2012.886
Published online Aug. 23, 2012

Patent application filed; available for licensing

Lin, Y.-D. et al. Sci. Transl. Med.;

published online Aug. 8, 2012;
doi:10.1126/scitranslmed.3003841
Contact: Patrick C.H. Hsieh,

National Cheng Kung University Hospital, Tainan, Taiwan
e-mail:
phsieh@mail.ncku.edu.tw