Thursday, August 23, 2012
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VEGF-containing, self-assembling peptide nanofiber scaffolds for
self-assembling peptide nanofiber scaffolds could help promote tissue repair
following myocardial infarction (MI). In rat and porcine models of MI,
intramyocardial injection of the VEGF-containing nanofiber scaffold increased
cardiac function, angiogenesis and arteriogenesis compared with injection of
scaffold or VEGF alone. In the rat model, intramyocardial injection of the
VEGF-containing nanofiber scaffold decreased systemic adverse effects
compared with injection of VEGF itself. Next steps include studies to
evaluate the scaffold's long-term effects and determine its therapeutic
window in the post-MI setting.
Published online Aug. 23, 2012
Patent application filed;
available for licensing
Lin, Y.-D. et al. Sci.
published online Aug. 8,
Contact: Patrick C.H. Hsieh,
National Cheng Kung
University Hospital, Tainan, Taiwan
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