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Disease models

Mouse model of systemic lupus erythematosus (SLE) induced by nucleic acid-containing amyloid fibrils

A mouse model of SLE induced by nucleic acid-containing amyloid fibrils could help screen and evaluate potential lupus therapies. In healthy mice, immunization with DNA-containing amyloid fibrils induced a rapid interferon response, infiltration of plasmacytoid dendritic cells (pDCs) at the inoculation site, autoantibody production and proteinuria. In those mice, mAb-mediated depletion of pDCs decreased the interferon response and amyloid fibril-induced generation of several autoantibodies compared with IgG control. Next steps include developing additional SLE models using delivery of different types of amyloids to generate different types of autoantibodies.

SciBX 5(33); doi:10.1038/scibx.2012.882
Published online Aug. 23, 2012

Unpatented; model available for licensing

Di Domizio, J. et al. Proc. Natl. Acad. Sci. USA; published online Aug. 17, 2012;
Contact: Wei Cao, The University of Texas MD Anderson Cancer Center, Houston, Texas