Thursday, August 23, 2012
Publication and contact
Induced pluripotent stem
(iPS) cell-derived motor neurons from patients with familial amyotrophic
lateral sclerosis (ALS) for in vitro therapeutic screening
In vitro studies suggest iPS cell-derived motor neurons from
patients with familial ALS could be used to screen for new therapeutics. In
cultured iPS cell-derived motor neurons from patients with familial ALS
carrying TAR DNA
binding protein 43
mutations, levels of TDP-43 protein and cytosolic aggregates were greater
than those in iPS cell-derived motor neurons from healthy controls. In the
ALS patient-derived motor neurons, the histone
acetyltransferase inhibitor anacardic
acid reversed the disease phenotype. Next steps include testing
the safety and efficacy of anacardic acid in additional cellular and animal
Published online Aug. 23, 2012
Patent application filed
covering prophylactic and therapeutic applications of anacardic acid;
provisional application filed covering screening applications; available for
Egawa, N. et al. Sci.
published online Aug. 1,
Contact: Haruhisa Inoue, Japan Science and Technology Agency,
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]