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Biofilm-resistant polymers

Mouse and in vitro studies suggest methacrylate polymer coatings could help prevent biofilm formation in implantable medical devices. A microarray-based screen identified a class of methacrylates that resisted colonization by Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. In a mouse model of biofilm formation, subcutaneously implanted catheters coated with the lead methacrylates showed less bacterial colonization than control catheters. Next steps include toxicology studies and preclinical testing of coated urinary and venous catheters.
Semprus BioSciences Corp. has biofilm-resistant polymer coatings for a range of biomedical devices in preclinical development (see Keeping biofilms at bay, page 8).

SciBX 5(33); doi:10.1038/scibx.2012.878
Published online Aug. 23, 2012

Patent pending; available for licensing

Hook, A.L. et al. Nat. Biotechnol.;

published online Aug. 12, 2012;
Contact: Morgan R. Alexander,

The University of Nottingham, Nottingham, U.K.