Thursday, August 23, 2012
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Mouse and in vitro
studies suggest methacrylate polymer coatings could
help prevent biofilm formation in implantable medical devices. A
microarray-based screen identified a class of methacrylates that resisted
colonization by Pseudomonas aeruginosa, Staphylococcus aureus
and Escherichia coli. In a mouse model of biofilm formation,
subcutaneously implanted catheters coated with the lead methacrylates showed
less bacterial colonization than control catheters. Next steps include
toxicology studies and preclinical testing of coated urinary and venous catheters.
BioSciences Corp. has biofilm-resistant
polymer coatings for a range of biomedical devices in preclinical development
biofilms at bay, page 8).
Published online Aug. 23, 2012
Patent pending; available
Hook, A.L. et al. Nat.
published online Aug. 12,
Contact: Morgan R. Alexander,
The University of
Nottingham, Nottingham, U.K.
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