Thursday, August 16, 2012
Publication and contact
Genetic lineage markers for
identifying glioma cancer stem cells
Mouse studies suggest
cell-specific expression of GFP-based genetic elements could be useful for
identifying compounds that target glioma stem cells. Transgenic mice were
engineered to develop gliomas that consist of a large population of highly
proliferative GFP-negative cells and a small population of quiescent
GFP-positive cells. Chemotherapy eradicated GFP-negative tumor cells but not
GFP-positive tumor cells. When chemotherapy was discontinued in these mice,
the quiescent GFP-positive tumor cells gradually gave rise to a large
population of highly proliferative and differentiated GFP-negative tumor
cells. In this model, selective ablation of the GFP-positive cells, even in
the absence of chemotherapy, blocked tumor growth and significantly increased
survival compared with no ablation (p=0.001). Next steps include pooling gliomas from
multiple mice and using them in a high throughput small molecule screen (see Tracing cancer stem cells, page 1).
SciBX 5(32); doi:10.1038/scibx.2012.854
Published online Aug. 16, 2012
status not applicable
Chen, J. et al. Nature; published online Aug. 1, 2012;
Contact: Luis F. Parada, The University of Texas
Southwestern Medical Center, Dallas, Texas
All contents Copyright © 1993-2016 BioCentury Publications, Inc. ALL RIGHTS RESERVED. All use of this Web Site and its contents is governed by the BioCentury User Agreement
. The contents of this Web Site are protected under U.S. and foreign copyright and intellectual property laws, and no part of this Web Site or its contents may be photocopied, reproduced or retransmitted in any form without the written consent of BioCentury, which may be requested from Reprints/Permissions
. BioCentury®; The Bernstein Report on BioBusiness™; The BioCentury 100™; The Clear Route to ROI™; Because Real Intelligence is Hard to Find™; BCIQ™; and BioPharma's Knowledge Center™; are trademarks of BioCentury Publications, Inc., P.O. Box 1246, San Carlos, CA 94070. SciBX® and SciBX: Science-Business eXchange® are trademarks of Nature America, Inc. that are jointly used by BioCentury Publications, Inc. and Nature America, Inc.
Thanks for purchasing this article.
Please bookmark this url for future reference.
We have also sent you a confirming e-mail with a receipt and this same url for your
close [ X ]