Glucocorticoids are standard of care for a host of
allergic and inflammatory eye conditions, but they elevate intraocular pressure
about a third of the time and can result in secondary open-angle glaucoma. A
chemical chaperone called sodium phenylbutyrate
could eliminate that side effect, according to new research from The University of Iowa.1
Sheffield said that his group is going to collaborate with
the Department of Ophthalmology at the University of Iowa to test whether PBA
can prevent IOP elevation in patients treated with glucocorticoids. "Our
plan is to formulate a PBA eye drop, but the details are not in place at this
time," he said.
the longer term, Sheffield's group wants to use PBA more broadly in primary
Boettner, B. SciBX 7(22);
doi:10.1038/scibx.2014.634 Published online June 5, 2014
1. Zode, G.S. et al. J. Clin. Invest.;
published online May 1, 2014; doi:10.1172/JCI69774 Contact:
Val C. Sheffield, The University of Iowa, Iowa City, Iowa e-mail: firstname.lastname@example.org
Contact: Gulab S. Zode, University of North Texas
Health Science Center, Fort Worth, Texas e-mail: email@example.com
2. Jones, R. 3rd & Rhee, D.J. et al. Curr.
Opin. Ophthalmol. 17, 163-167 (2006)
3. Zode, G.S. et al. J. Clin. Invest. 121, 3542-3553 (2011)
AND INSTITUTIONS MENTIONED
(NYSE:AGN), Irvine, Calif.
Cambridge Institute for Medical Research, Cambridge, U.K.
Howard Hughes Medical Institute, Chevy Chase, Md.
Medical Research Council, London, U.K.
Merck & Co. Inc. (NYSE:MRK), Whitehouse Station, N.J.
Swedish Orphan Biovitrum AB (SSE:SOBI), Stockholm, Sweden
University of California, San Diego, La Jolla, Calif.
University of California, San Diego School of Medicine, La Jolla, Calif.
The University of Iowa, Iowa City, Iowa
University of North Texas Health Science Center, Fort Worth, Texas
University of Pittsburgh Medical Center, Pittsburgh, Pa.
University of Pittsburgh School of Medicine, Pittsburgh, Pa.
Valeant Pharmaceuticals International Inc. (TSX:VRX; NYSE:VRX), Montreal, Quebec, Canada