Preclinical data showing that microRNA-25
inhibition can help treat heart failure directly contradict a 2013 paper
suggesting that decreased levels of the miRNA provoke the condition.1,2
Although the new study shows that blocking microRNA-25 restores levels of the SERCA2A
calcium uptake channel-and thus improves cardiac contractility-the discrepancy
with the earlier result needs resolving before a microRNA-25-based therapy can
Several researchers told SciBX that the first step
should be to reconcile the results with the conflicting data from the
De Windt told SciBX that his team now plans to
develop a cardiac-specific miR-25 knockout mouse model. He said that
would give a definitive answer about how the miRNA is involved in mouse heart
Celladon's Zsebo is not convinced that an
oligonucleotide-based approach will upregulate SERCA2A as effectively as
gene therapy, despite the fact that anti-miR-25 may affect multiple
dysregulated pathways in heart failure, including SERCA2A.
Martz, L. SciBX 7(16);
doi:10.1038/scibx.2014.450 Published online April 24, 2014
1. Wahlquist, C. et al. Nature; published online March
12, 2014; doi:10.1038/nature13073 Contact:
Mark Mercola, Sanford-Burnham
Medical Research Institute, La Jolla, Calif. e-mail: firstname.lastname@example.org
2. Dirkx, E. et al. Nat. Cell Biol. 15, 1282-1293 (2013)
3. Kawase, Y. et al. J. Am. Coll. Cardiol. 51, 1112-1119 (2008)
4. Jessup, M. et al. Circulation 124, 304-313 (2011)
5. Ikeda, S. et al. Physiol. Genomics 31, 367-373 (2007)
AND INSTITUTIONS MENTIONED
(NASDAQ: CLDN), San Diego, Calif.
Gwangju Institute of Science and Technology, Gwangju, South Korea
Icahn School of Medicine at Mount Sinai, New York, N.Y.
ICIN Netherlands Heart Institute, Utrecht, the Netherlands
Maastricht University, Maastricht, the Netherlands
miRagen Therapeutics Inc., Boulder, Colo.
Mount Sinai Hospital, New York, N.Y.
Regulus Therapeutics Inc. (NASDAQ:RGLS), San Diego, Calif.
Sanford-Burnham Medical Research Institute, La Jolla, Calif.
University of California, San Diego, La Jolla, Calif.
University Medical Center Utrecht, Utrecht, the Netherlands