Thursday, April 3, 2014
of the dominant problems after coronary artery bypass graft surgery is
hyperplastic growth inside the transplanted blood vessel that can lead to
stenosis. Now, a team at the NIH's
National Heart, Lung, and Blood Institute has found that this
hyperplasia is rooted in a change in the phenotype of endothelial cells lining
the transplanted veins and has shown that blocking transforming growth factor-b activity in mice
can significantly slow the cellular changes.1
To find out whether neointima derive from the graft itself
or are formed by VSMCs from distant sites in the recipient mice, Boehm's team
removed jugular veins containing fluorescently labeled endothelia from
transgenic donor mice and grafted them into the femoral artery of
nonfluorescent recipient mice.
Of pigs and
Bradshaw, a research fellow at the University of Glasgow Institute of Cardiovascular and
Medical Sciences, told SciBX, "The study has undoubtedly
made an important contribution to our understanding of how TGFb promotes vein graft
Boettner, B. SciBX
7(13); doi:10.1038/scibx.2014.362 Published online April 3, 2014
1. Cooley, B.C. et al. Sci. Transl. Med.; published
online March 12, 2014; doi:10.1126/scitranslmed.3006927 Contact:
Manfred Boehm, National Heart, Lung, and Blood Institute, Bethesda, Md. e-mail:
2. van Meeteren, L.A. & ten Dijke, P. Cell Tissue Res. 347, 177-186 (2012)
3. Khan, R. et al. Cardiovasc. Res. 74,
AND INSTITUTIONS MENTIONED
Leiden, the Netherlands
Leiden University Medical Center, Leiden, the Netherlands
Merck & Co. Inc. (NYSE:MRK), Whitehouse Station, N.J.
National Heart, Lung, and Blood Institute, Bethesda, Md.
National Institutes of Health, Bethesda, Md.
University of Bristol School of Clinical Sciences, Bristol, U.K.
University of Glasgow Institute of Cardiovascular and
Medical Sciences, Glasgow,