BioCentury
ARTICLE | Targets & Mechanisms

Negative nanoparticles

February 6, 2014 8:00 AM UTC
Updated on Oct 22, 2019 at 8:59 PM UTC

A simple experimental error has opened up the potential for nanoparticles to treat disease rather than be used only as payloads. By accidentally using negatively charged nanoparticles instead of neutral ones, a team from Northwestern University and The University of Sydney saw selective tagging of inflammatory monocytes for destruction.1

Their spinout, Cour Pharmaceutical Development Co. Inc., is testing the particles in myocardial infarction (MI) and plans to enter Phase I testing within a year...