Thursday, August 22, 2013
Despite evidence that pathologic TAU spreads through the
brain in tauopathies such as Alzheimer's disease and frontotemporal dementia,
the actual mechanism by which the misfolded protein propagates is murky. A key player
in the process are heparan sulfate
proteoglycans, according to new findings from the Washington University in St. Louis.1
L. SciBX 6(32);
doi:10.1038/scibx.2013.848 Published online Aug. 22, 2013
1. Holmes, B.B. et al.
Proc. Natl. Acad. Sci. USA; published online July 29, 2013;
doi:10.1073/pnas.1301440110 Contact: Marc I. Diamond, Washington
University in St. Louis School of Medicine, St. Louis, Mo. e-mail: firstname.lastname@example.org
2. Nakajima, M. et al.
Science 220, 611-613 (1983)
3. Horonchik, L. et al.
J. Biol. Chem. 280, 17062-17067 (2005)
4. Frost, B. et al. J.
Biol. Chem. 284, 12845-12852 (2009)
5. Kfoury, N. et al. J.
Biol. Chem. 287, 19440-19451 (2012)
AND INSTITUTIONS MENTIONED
BioArctic Neuroscience AB, Stockholm, Sweden
Eisai Co. Ltd. (Tokyo:4523; Osaka:4523), Tokyo, Japan
Enkam Pharmaceuticals A/S, Copenhagen, Denmark
Paris 12 Val de Marne University, Creteil, France
University of California, Berkeley School of Optometry, Berkeley, Calif.
University of California, San Francisco, Calif.
University of Virginia, Charlottesville, Va.
Washington University in St. Louis, St. Louis, Mo.
Washington University in St. Louis School of Medicine, St. Louis, Mo.