Thursday, April 25, 2013
I interferon receptors are key factors that promote antiviral
immunity, but two separate teams have found that elevated interferon signaling may actually be
detrimental to the body's ability to fight persistent infections. Groups at The Scripps Research Institute and the University of California, Los Angeles showed
that blocking type I interferon during
the persistent stages of viral infections in mice can resolve the infections.1,2
Chronicles of interferon
L. SciBX 6(16);
Published online April 25, 2013
1. Teijaro, J.R. et al.
Science; published online April 12, 2013; doi:10.1126/science.1235214
Contact: Michael B.A. Oldstone, The Scripps Research Institute, La
2. Wilson, E.B. et
al. Science; published online April 12, 2013; doi:10.1126/science.1235208
Contact: David G. Brooks, University of California, Los Angeles, Calif.
3. Appay, V. & Sauce,
D. J. Pathol. 214, 231-241 (2008)
4. Zinselmeyer, B.H. et
al. J. Exp. Med. 210, 757-774 (2013)
Argos Therapeutics Inc., Durham, N.C.
Cincinnati Children's Research Foundation, Cincinnati, Ohio
The Scripps Research Institute, La Jolla, Calif.
University of California, Los Angeles, Calif.
University of Cincinnati College of Medicine, Cincinnati, Ohio
Vaccine & Gene Therapy Institute of Florida, Port St. Lucie, Fla.
Washington University in St. Louis School of Medicine, St. Louis, Mo.