Giving the NOD2 microbiota

Disruption of enteric microbiota occurs in inflammatory bowel diseases, but whether this is a cause or result of the condition is unclear. Now, European researchers have shed light on the process by showing that a deficiency in an immune system-related receptor, NOD2, can disrupt enteric microbiota and set the stage for colitis and colitis-associated cancer.¹

The group now is looking for bacterial strains that could help correct the microbial imbalance and is trying to better understand why a deficiency in caspase recruitment domain family member 15 (NOD2; CARD15) causes the disruption in the first place...