there is widespread agreement on the need for a better way to diagnose
preeclampsia, few companies have pursued new tests because finding specific
markers has been difficult. A Yale-led group has
found dye-binding aggregates of misfolded proteins that could be markers for preeclampsia and has developed a simple urine test that can
rapidly diagnose the condition.1
told SciBX that her team developed the technology to address the limits
of current diagnostic criteria. The aim was to improve preeclampsia
determination by using the test in addition to those criteria or instead of
Buhimschi and two of her team members prepare for an international clinical
trial of the diagnostic, the test's accuracy leaves open the question of whether
it is likely to have greater uptake in the developed world or in developing
Haas, M.J. SciBX 7(30); doi:10.1038/scibx.2014.882 Published online Aug.
1. Buhimschi, I.A. et
al. Sci. Transl. Med.; published online July 16, 2014;
doi:10.1126/scitranslmed.3008808 Contact: Irina A. Buhimschi, The
Research Institute at Nationwide Children's Hospital, Columbus, Ohio e-mail: email@example.com
I.A. et al. Am. J. Obstet. Gynecol. 199, 551.e1-551.e16
3. Huntington, J.A. J.
Thromb. Haemost. 9, 26-34 (2011)
4. Khurana, R. et al.
J. Biol. Chem. 276, 22715-22721 (2001)
AND INSTITUTIONS MENTIONED
Carmenta Bioscience Inc., Palo Alto, Calif.
GestVision Inc., Guilford, Conn.
King Abdulaziz University, Jeddah, Saudi Arabia
Nationwide Children's Hospital, Columbus, Ohio
New York University School of Medicine, New York, N.Y.
The Ohio State University, Columbus, Ohio
The Ohio State University College of Medicine, Columbus, Ohio
Saving Lives at Birth, Washington, D.C.
(Xetra:SIE; NYSE:SI), Munich, Germany
University of California, Irvine, Calif.
The University of Vermont School of Medicine, Burlington, Vt.
U.S. Agency for International Development, Washington, D.C.
Yale School of Medicine, New Haven, Conn.