Thursday, June 12, 2014
Nav1.7 entered the limelight in the last decade as
a pain target that could provide wide-ranging analgesia, but it has been
difficult to target selectively over other voltage-gated sodium channels. Now,
a team at the Duke University has found a unique epitope on Nav1.7
and used it to create a highly selective antibody that blocks the channel by
locking it in a closed state.1
King, a professor in the Division of Chemistry and Structural Biology at The University of Queensland's Institute of
Molecular Bioscience, told SciBX, "I think this is the most
important paper on Nav1.7 since the original observation reported in Nature
said that the next step will be for the Duke team to create a humanized version
of the Nav1.7 antibody that retains the specificity of the mouse antibody and
optimize its pharmacokinetic properties.
L. SciBX 7(23); doi:10.1038/scibx.2014.662
Published online June 12, 2014
1. Lee, J.-H. et al. Cell; published online May
Seok-Yong Lee, Duke
University Medical Center, Durham, N.C.
Ru-Rong Ji, same affiliation as above
2. Cox, J.J. et al. Nature 444, 894-898 (2006)
3. Payandeh, J. et al. Nature 475, 353-358 (2011)
AND INSTITUTIONS MENTIONED
Rotterdam, the Netherlands
Duke University Medical Center, Durham, N.C.
Saarland University Medical Center, Homburg, Germany
SiteOne Therapeutics Inc., Redwood City, Calif.
University of Cambridge, Cambridge, U.K.
The University of Queensland, Brisbane, Queensland, Australia
University of Washington, Seattle, Washington