Thursday, January 9, 2014
Poor tumor definition is a central challenge in cancer
surgery, which aims to remove all malignant cells while preserving normal
tissue. Now, a team from The University of Texas Southwestern Medical Center has
designed fluorescent nanoparticles that can light up tumors regardless of
genotype or phenotype.1 The approach could allow surgeons to achieve
more complete tumor resection.
Let there be
To create the on/off nanoparticles, the team developed ultra
sensitive (UPS) nanoprobes that differentiated
between the relatively close pH values found in blood and in the extracellular
microenvironment of tumor cells (see "Ultra
pH-sensitive (UPS) nanoprobes shed new light on tumors").
Light at the
end of the clinic
Since publishing the study, the Texas team has adapted the
technology to incorporate indocyanine green, an FDA-approved near-infrared dye.
Baas, T. SciBX 7(1); doi:10.1038/scibx.2014.1
Published online Jan. 9, 2014
1. Wang, Y. et al. Nat.
Mater.; published online Dec. 8, 2013; doi:10.1038/nmat3819
Contact: Jinming Gao, The University of Texas Southwestern Medical Center,
2. Urano, Y. et
al. Nat. Med. 15, 104-109 (2009)
3. van Dam, G.M. et
al. Nat. Med. 17, 1315-1319 (2011)
4. Ke, S. et
al. Cancer Res. 63, 7870-7875 (2003)
5. Zhou, K. et
al. Angew. Chem. Int. Ed. 50, 6109-6114 (2011)
AND INSTITUTIONS MENTIONED
Blaze Bioscience Inc., Seattle, Wash.
Dune Medical Devices Ltd., Caesarea Industrial Park, Israel
Kinetic Concepts Inc., San Antonio, Texas
LifeCell Corp. (NASDAQ:LIFC), Branchburg, N.J.
Purdue University, West Lafayette, Ind.
University of Groningen, Groningen, the Netherlands
The University of Texas Southwestern Medical Center, Dallas, Texas