Sage climbs on Phase II MDD readout
Sage Therapeutics Inc. (NASDAQ:SAGE) Sage jumped $5.57 (12%) to $52.99 on Monday after it said SAGE-217 significantly reduced depression ratings in the first part of a Phase II trial to treat severe major depressive disorder in adults. The results met criteria for starting the trial's placebo-controlled second part, Sage said.
Among 13 patients in the trial's open-label first part, Sage said once-daily oral SAGE-217 significantly reduced mean Hamilton Rating Scale for Depression (HAM-D) total scores from a baseline of 27.2 to 7.3 at day 15 (p<0.0001). The primary endpoint measured safety and tolerability. Sage said SAGE-217 was generally well tolerated with no serious adverse events or discontinuations...
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