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ARTICLE | Clinical News

Novo reports Phase III data for hemophilia B compound

May 18, 2013 12:04 AM UTC

Novo Nordisk A/S (CSE:NVO; NYSE:NVO) reported data on Friday from the 74-patient Phase III paradigm 2 trial evaluating N9-GP -- a glyco-pegylated derivative of recombinant human Factor IX -- to treat and prevent bleeding episodes in patients with hemophilia B. Once-weekly 10 and 40 U/kg doses of N9-GP as prophylaxis for 12 months reduced median annualized bleeding rates compared to on-demand treatment with N9-GP for six months (2.9 and 1 episode per year, respectively, vs. 15.6 episodes per year). According to clinicaltrials.gov, the primary endpoint of the trial was incidence of inhibitory antibodies against Factor IX. Novo Nordisk declined to disclose details. ...