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Boehringer picks Polyphor's macrocycle discovery tech for its smallness
Mini-macrocycle marriage
By Michael Flanagan
Senior Writer
Published on
Monday, July 16, 2012
Polyphor
Ltd. has signed its first MacroFinder discovery deal, attracting Boehringer
Ingelheim GmbH with the technology's capacity for generating smaller
macrocycle therapeutics that offer better pharmaceutical properties and cell
permeability than competing technologies.
Macrocycles typically are
500-2,000 Da. in size, which makes them larger than most small molecules but
smaller than biologics. They are found in many natural products and
feature a ring structure that allows for stability and structural organization
of functional subunits (see SciBX: Science-Business eXchange, Jan. 26).
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