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Polymer gene delivery
Monday, February 5, 2001
In order to reach the nucleus, a gene therapy vector must escape the
endosome - a lipid vesicle that internally buds off from the cell membrane - or else it
will be transported to the lysosome and degraded. Researchers at the Massachusetts
Institute of Technology believe they have created a synthetic polymer gene delivery system
that allows for such endosomal escape and gives comparable transfection as existing
cationic systems, with the potential for less cytotoxicity.
The system is not ready to plug
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