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Collateral likes the angiogenesis treadmill
Monday, March 27, 2000
Although Chiron Corp. may have concluded that treadmill exercise time
might not be the best end point for testing angiogenesis compounds in cardiovascular
conditions, Collateral Therapeutics Inc. believes that the treadmill has successfully
pointed it toward pivotal studies of its gene therapy for angina.
CHIR's fibroblast growth factor-2 (FGF-2) recently failed to
show significant impact on exercise time in a Phase II study in angina. The
company (Emeryville, Calif.) suggested that a high placebo effect, plus the
ability of patients to stop exercising for reasons other than angina, had shown
the exercise measure needs to be
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