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Tools & Techniques
Glimmer of hope for pimagedine
Tuesday, June 1, 1999
It's usually futile to turn secondary end points into primary
end points when a compound has failed its first set of pivotal trials. But Alteon Inc. thinks the effort is worth a shot for its pimagedine inhibitor of advanced
glycosylation end products (A.G.E.s) in Type I diabetes, based on new knowledge
about the role of proteinuria in kidney disease.
The company's original Phase III ACTION I study failed to meet
its primary end point of reducing the risk of doubling serum creatinine
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