Tissue plasminogen activator (tPA) has been found to dissolve blood clots effectively, an activity useful both in treating heart attack and stroke. However, in humans the effects of tPA in stroke cannot be studied apart from the drug's thrombolytic effects. Harvard researchers have now examined the effects of tPA separately from its cardiovascular properties by inducing strokes in mice through occlusion of the middle cerebral artery.

In Nature Medicine, they